This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parkin, N. T.
Right arrow Articles by Petropoulos, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parkin, N. T.
Right arrow Articles by Petropoulos, C. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2006, p. 351-354, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.351-354.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The K101P and K103R/V179D Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nonnucleoside Reverse Transcriptase Inhibitors

Neil T. Parkin,* Soumi Gupta, Colombe Chappey, and Christos J. Petropoulos

Monogram Biosciences, 345 Oyster Point Boulevard, South San Francisco, California 94080

Received 23 August 2005/ Returned for modification 26 September 2005/ Accepted 4 October 2005

Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n > 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n = 35) or a combination of K103R and V179D (n = 41). Site-directed mutagenesis confirmed the importance of these mutations.

* Corresponding author. Mailing address: Monogram Biosciences, Inc., 345 Oyster Point Blvd., South San Francisco, CA 94080. Phone: (650) 866-7438. Fax: (650) 635-1111. E-mail: nparkin{at}monogrambio.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 351-354, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.351-354.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»