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Antimicrobial Agents and Chemotherapy, January 2006, p. 355-358, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.355-358.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

blaIMP-9 and Its Association with Large Plasmids Carried by Pseudomonas aeruginosa Isolates from the People's Republic of China

Jianhui Xiong,1,2 Michael F. Hynes,3 Huifen Ye,2 Huiling Chen,2 Yinmei Yang,2 Fatima M'Zali,4 Peter M. Hawkey,1* the Guangzhou Antibiotic Resistance Study Group

Division of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom,1 Department of Laboratory Medicine, 1st Municipal People's Hospital of Guangzhou, 510180 Guangzhou, People's Republic of China,2 Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada,3 Division of Microbiology, University of Leeds, LS2 9JT Leeds, United Kingdom4

Received 13 May 2005/ Returned for modification 5 July 2005/ Accepted 22 October 2005

A novel plasmid-mediated metallo-ß-lactamase (IMP-9) is described in seven isolates of Pseudomonas aeruginosa from Guangzhou, China, isolated in 2000. The gene was carried on a large (~450-kb) IncP-2 conjugative plasmid. This is the first report of carriage of blaIMP genes on such large plasmids.

* Corresponding author. Mailing address: Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heartlands and Solihull NHS Trust, Bordesley Green East, Birmingham B9 5SS, United Kingdom. Phone: 44 (0) 121 424 1240. Fax: 44 (0) 121 772 6229. E-mail: peter.hawkey{at}heartofengland.nhs.uk.

Antimicrobial Agents and Chemotherapy, January 2006, p. 355-358, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.355-358.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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