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Antimicrobial Agents and Chemotherapy, January 2006, p. 362-364, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.362-364.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Lethal Action of Quinolones against a Temperature-Sensitive dnaB Replication Mutant of Escherichia coli

Xilin Zhao, Muhammad Malik, Nymph Chan, Alex Drlica-Wagner, Jian-Ying Wang, Xinying Li, and Karl Drlica*

Public Health Research Institute, 225 Warren St., Newark, New Jersey 07103

Received 8 September 2005/ Returned for modification 6 October 2005/ Accepted 25 October 2005

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

* Corresponding author. Mailing address: Public Health Research Institute, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3360. E-mail: drlica{at}phri.org.

Antimicrobial Agents and Chemotherapy, January 2006, p. 362-364, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.362-364.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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