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Antimicrobial Agents and Chemotherapy, January 2006, p. 371-373, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.371-373.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

Sandrine Marchand,1,2 Anna Forsell,1 Marylore Chenel,1,3 Emmanuelle Comets,4 Isabelle Lamarche,1 and William Couet1,2*

EA 3809, Faculté de Médecine et de Pharmacie, BP 199, 34 rue du Jardin des Plantes, 86005 Poitiers Cedex, France,1 Laboratoire de Pharmacocine'tique, PBS, CHU La Mile'trie, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France,2 University of Manchester, Manchester, United Kingdom,3 INSERM U738, Department of Epidemiology, Biostatistics and Clinical research, AP-HP, Bichat University Hospital, Paris, France4

Received 9 March 2005/ Returned for modification 22 May 2005/ Accepted 30 October 2005

The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.

* Corresponding author. Mailing address: Pôle Biologie Santé, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France. Phone: 33-5-49-45-43-79. Fax: 33-5-49-45-43-78. E-mail: william.couet{at}univ-poitiers.fr.

Antimicrobial Agents and Chemotherapy, January 2006, p. 371-373, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.371-373.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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