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Antimicrobial Agents and Chemotherapy, January 2006, p. 379-381, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.379-381.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activities of Retapamulin (SB-275833) against 141 Clinical Isolates of Propionibacterium spp., Including 117 P. acnes Isolates

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 and Helen T. Fernandez1

R. M. Alden Research Laboratory, Santa Monica, California 90404,1 UCLA School of Medicine, Los Angeles, California 900732

Received 30 June 2005/ Returned for modification 30 September 2005/ Accepted 10 October 2005

Using the NCCLS agar dilution method, we studied the in vitro activity of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among those tested with MICs of ≤1 µg/ml against all isolates.

* Corresponding author. Mailing address: R. M. Alden Research Laboratory, 2021 Santa Monica Blvd. Suite 740 E, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 379-381, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.379-381.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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