This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borriello, G.
Right arrow Articles by Stewart, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borriello, G.
Right arrow Articles by Stewart, P. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 2006, p. 382-384, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.382-384.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Arginine or Nitrate Enhances Antibiotic Susceptibility of Pseudomonas aeruginosa in Biofilms

Giorgia Borriello,1 Lee Richards,1 Garth D. Ehrlich,2 and Philip S. Stewart1*

Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University—Bozeman, Bozeman, Montana 59717-3980,1 Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E. North Ave., Pittsburgh, Pennsylvania 152122

Received 1 June 2005/ Returned for modification 1 July 2005/ Accepted 10 October 2005

Arginine enhanced the killing of Pseudomonas aeruginosa by ciprofloxacin and tobramycin under anaerobic, but not aerobic, growth conditions. Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone.

* Corresponding author. Mailing address: Center for Biofilm Engineering, Montana State University—Bozeman, 409 Cobleigh Hall, Bozeman, MT 59717-3980. Phone: (406) 994-4770. Fax: (406) 994-6098. E-mail: phil_s{at}erc.montana.edu.

Antimicrobial Agents and Chemotherapy, January 2006, p. 382-384, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.382-384.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Barraud, N., Schleheck, D., Klebensberger, J., Webb, J. S., Hassett, D. J., Rice, S. A., Kjelleberg, S. (2009). Nitric Oxide Signaling in Pseudomonas aeruginosa Biofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal. J. Bacteriol. 191: 7333-7342 [Abstract] [Full Text]  
  • Platt, M. D., Schurr, M. J., Sauer, K., Vazquez, G., Kukavica-Ibrulj, I., Potvin, E., Levesque, R. C., Fedynak, A., Brinkman, F. S. L., Schurr, J., Hwang, S.-H., Lau, G. W., Limbach, P. A., Rowe, J. J., Lieberman, M. A., Barraud, N., Webb, J., Kjelleberg, S., Hunt, D. F., Hassett, D. J. (2008). Proteomic, Microarray, and Signature-Tagged Mutagenesis Analyses of Anaerobic Pseudomonas aeruginosa at pH 6.5, Likely Representing Chronic, Late-Stage Cystic Fibrosis Airway Conditions. J. Bacteriol. 190: 2739-2758 [Abstract] [Full Text]  
  • Jurcisek, J. A., Bakaletz, L. O. (2007). Biofilms Formed by Nontypeable Haemophilus influenzae In Vivo Contain both Double-Stranded DNA and Type IV Pilin Protein. J. Bacteriol. 189: 3868-3875 [Abstract] [Full Text]  
  • Garo, E., Eldridge, G. R., Goering, M. G., Pulcini, E. D., Hamilton, M. A., Costerton, J. W., James, G. A. (2007). Asiatic Acid and Corosolic Acid Enhance the Susceptibility of Pseudomonas aeruginosa Biofilms to Tobramycin. Antimicrob. Agents Chemother. 51: 1813-1817 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»