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Antimicrobial Agents and Chemotherapy, January 2006, p. 382-384, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.382-384.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Arginine or Nitrate Enhances Antibiotic Susceptibility of Pseudomonas aeruginosa in Biofilms

Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University—Bozeman, Bozeman, Montana 59717-3980,¹ Center for Genomic Sciences, Allegheny Singer Research Institute, 320 E. North Ave., Pittsburgh, Pennsylvania 15212²

Received 1 June 2005/ Returned for modification 1 July 2005/ Accepted 10 October 2005

Arginine enhanced the killing of Pseudomonas aeruginosa by ciprofloxacin and tobramycin under anaerobic, but not aerobic, growth conditions. Arginine or nitrate also enhanced the killing by these antibiotics in mature biofilms, reducing viable cell counts by a factor of 10 to 100 beyond that achieved by antibiotics alone.

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