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Antimicrobial Agents and Chemotherapy, January 2006, p. 385-387, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.385-387.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

Ed T. Buurman,1* Kenneth D. Johnson,1 Roxanne K. Kelly,2 and Kathy MacCormack2

Department of Microbiology,1 Molecular Sciences, Infection Discovery, AstraZeneca R&D Boston, Waltham, Massachusetts 024512

Received 25 July 2005/ Returned for modification 23 August 2005/ Accepted 25 August 2005

Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

* Corresponding author. Mailing address: AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451. Phone: (781) 839-4592. Fax: (781) 839-4800. E-mail: Ed.Buurman{at}astrazeneca.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 385-387, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.385-387.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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