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Antimicrobial Agents and Chemotherapy, January 2006, p. 391-395, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.391-395.2006

Dexamethasone Attenuates Staphylococcal Enterotoxin B-Induced Hypothermic Response and Protects Mice from Superantigen-Induced Toxic Shock

Teresa Krakauer* and Marilyn Buckley

Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011

Received 13 August 2005/ Returned for modification 14 September 2005/ Accepted 30 September 2005

The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock.

* Corresponding author. Mailing address: Integrated Toxicology Division, 1425 Porter Street, USAMRIID, Fort Detrick, Frederick, MD 21702-5011. Phone: (301) 619-4733. Fax: (301) 619-2348. E-mail: teresa.krakauer{at}det.amedd.army.mil.

Antimicrobial Agents and Chemotherapy, January 2006, p. 391-395, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.391-395.2006






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