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Antimicrobial Agents and Chemotherapy, January 2006, p. 396-398, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.396-398.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Rifampin Augments Cytokine-Induced Nitric Oxide Production in Human Alveolar Epithelial Cells

Yael Yuhas,1,3* Eva Berent,1 Hila Ovadiah,1 Inbar Azoulay,1,3 and Shai Ashkenazi1,2,3

Felsenstein Medical Research Center,1 Schneider Children's Medical Center, Beilinson Campus, Petah Tikva,2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel3

Received 11 September 2005/ Returned for modification 5 October 2005/ Accepted 29 October 2005

Rifampin increased nitric oxide production and inducible nitric oxide synthase expression in alveolar cells stimulated with cytokines. Nitric oxide concentrations after induction with cytokines, cytokines with 10 µg/ml rifampin, and cytokines with 50 µg/ml rifampin were 3.2, 4.5, and 8.8 µM, respectively (P < 0.02 versus cytokines alone). This indicates that rifampin modulates the immune response.

* Corresponding author. Mailing address: Laboratory of Infectious Diseases, Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva 49100, Israel. Phone: 972-3-9376736. Fax: 972-3-9253056. E-mail: yuhas{at}post.tau.ac.il.

Antimicrobial Agents and Chemotherapy, January 2006, p. 396-398, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.396-398.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yuhas, Y., Berent, E., Cohen, R., Ashkenazi, S. (2009). Roles of NF-{kappa}B Activation and Peroxisome Proliferator-Activated Receptor Gamma Inhibition in the Effect of Rifampin on Inducible Nitric Oxide Synthase Transcription in Human Lung Epithelial Cells. Antimicrob. Agents Chemother. 53: 1539-1545 [Abstract] [Full Text]  
  • Yuhas, Y., Azoulay-Alfaguter, I., Berent, E., Ashkenazi, S. (2007). Rifampin Inhibits Prostaglandin E2 Production and Arachidonic Acid Release in Human Alveolar Epithelial Cells. Antimicrob. Agents Chemother. 51: 4225-4230 [Abstract] [Full Text]  


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