This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marty, F. M.
Right arrow Articles by Baden, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marty, F. M.
Right arrow Articles by Baden, L. R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2006, p. 3450-3453, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00658-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Reactivity of (1->3)-ß-D-Glucan Assay with Commonly Used Intravenous Antimicrobials

Francisco M. Marty,1,2,3* Colleen M. Lowry,1 Steven J. Lempitski,4 David W. Kubiak,1 Malcolm A. Finkelman,4 and Lindsey R. Baden1,2,3

Brigham & Women's Hospital,1 Dana-Farber Cancer Institute,2 Harvard Medical School, Boston, Massachusetts,3 Associates of Cape Cod, Inc., East Falmouth, Massachusetts4

Received 30 May 2006/ Returned for modification 15 July 2006/ Accepted 31 July 2006

Forty-four intravenous antimicrobials were tested for the presence of (1->3)-ß-D-glucan (BG). Colistin, ertapenem, cefazolin, trimethoprim-sulfamethoxazole, cefotaxime, cefepime, and ampicillin-sulbactam tested positive for BG at reconstituted-vial concentrations but not when diluted to usual maximum plasma concentrations. False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed.

* Corresponding author. Mailing address: Division of Infectious Diseases, Brigham & Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115. Phone: (617) 732-8881. Fax: (617) 732-6829. E-mail: fmarty{at}partners.org.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3450-3453, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00658-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Del Bono, V., Mularoni, A., Furfaro, E., Delfino, E., Rosasco, L., Miletich, F., Viscoli, C. (2009). Clinical Evaluation of a (1,3)-{beta}-D-Glucan Assay for Presumptive Diagnosis of Pneumocystis jiroveci Pneumonia in Immunocompromised Patients. CVI 16: 1524-1526 [Abstract] [Full Text]  
  • Persat, F., Ranque, S., Derouin, F., Michel-Nguyen, A., Picot, S., Sulahian, A. (2008). Contribution of the (1->3)-{beta}-D-Glucan Assay for Diagnosis of Invasive Fungal Infections. J. Clin. Microbiol. 46: 1009-1013 [Abstract] [Full Text]  
  • Kikkert, R., Bulder, I., de Groot, E. R., Aarden, L. A., Finkelman, M. A. (2007). Potentiation of Toll-like receptor-induced cytokine production by (1->3)-{beta}-D-glucans: implications for the monocyte activation test. Innate Immunity 13: 140-149 [Abstract]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»