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Antimicrobial Agents and Chemotherapy, October 2006, p. 3450-3453, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00658-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Reactivity of (1->3)-ß-D-Glucan Assay with Commonly Used Intravenous Antimicrobials

Francisco M. Marty,1,2,3* Colleen M. Lowry,1 Steven J. Lempitski,4 David W. Kubiak,1 Malcolm A. Finkelman,4 and Lindsey R. Baden1,2,3

Brigham & Women's Hospital,1 Dana-Farber Cancer Institute,2 Harvard Medical School, Boston, Massachusetts,3 Associates of Cape Cod, Inc., East Falmouth, Massachusetts4

Received 30 May 2006/ Returned for modification 15 July 2006/ Accepted 31 July 2006

Forty-four intravenous antimicrobials were tested for the presence of (1->3)-ß-D-glucan (BG). Colistin, ertapenem, cefazolin, trimethoprim-sulfamethoxazole, cefotaxime, cefepime, and ampicillin-sulbactam tested positive for BG at reconstituted-vial concentrations but not when diluted to usual maximum plasma concentrations. False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed.

* Corresponding author. Mailing address: Division of Infectious Diseases, Brigham & Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115. Phone: (617) 732-8881. Fax: (617) 732-6829. E-mail: fmarty{at}partners.org.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3450-3453, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00658-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Persat, F., Ranque, S., Derouin, F., Michel-Nguyen, A., Picot, S., Sulahian, A. (2008). Contribution of the (1->3)-{beta}-D-Glucan Assay for Diagnosis of Invasive Fungal Infections. J. Clin. Microbiol. 46: 1009-1013 [Abstract] [Full Text]  
  • Kikkert, R., Bulder, I., de Groot, E. R., Aarden, L. A., Finkelman, M. A. (2007). Potentiation of Toll-like receptor-induced cytokine production by (1->3)-{beta}-D-glucans: implications for the monocyte activation test. Innate Immunity 13: 140-149 [Abstract]  


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