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Antimicrobial Agents and Chemotherapy, October 2006, p. 3454-3456, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00783-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Weak Mutators Can Drive the Evolution of Fluoroquinolone Resistance in Escherichia coli

Hanna Örlén and Diarmaid Hughes*

Department of Cell and Molecular Biology, Box 596, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden

Received 29 June 2006/ Returned for modification 12 July 2006/ Accepted 14 July 2006

Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.

* Corresponding author. Mailing address: Department of Cell and Molecular Biology, Box 596, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden. Phone: 46-18-471 4354. Fax: 46-18-530396. E-mail: diarmaid.hughes{at}icm.uu.se.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3454-3456, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00783-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mandsberg, L. F., Ciofu, O., Kirkby, N., Christiansen, L. E., Poulsen, H. E., Hoiby, N. (2009). Antibiotic Resistance in Pseudomonas aeruginosa Strains with Increased Mutation Frequency Due to Inactivation of the DNA Oxidative Repair System. Antimicrob. Agents Chemother. 53: 2483-2491 [Abstract] [Full Text]  
  • Gould, C. V., Sniegowski, P. D., Shchepetov, M., Metlay, J. P., Weiser, J. N. (2007). Identifying Mutator Phenotypes among Fluoroquinolone-Resistant Strains of Streptococcus pneumoniae Using Fluctuation Analysis. Antimicrob. Agents Chemother. 51: 3225-3229 [Abstract] [Full Text]  


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