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Antimicrobial Agents and Chemotherapy, October 2006, p. 3467-3469, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00670-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis

Lisa F. Shubitz,1,2 John N. Galgiani,2,3,4* Zong-Qiang Tian,5 Ziyang Zhong,5 Pieter Timmermans,5 and Leonard Katz5

Department of Veterinary Science and Microbiology,1 Department of Medicine, University of Arizona,3 Valley Fever Center for Excellence,2 Southern Arizona Veterans Health Care Administration, Tucson, Arizona,4 Kosan Biosciences, Inc., Hayward, California5

Received 1 June 2006/ Returned for modification 10 June 2006/ Accepted 15 July 2006

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

* Corresponding author. Mailing address: Valley Fever Center for Excellence, 3601 South Sixth Ave., Tucson, AZ 85723. Phone: (520) 629-4777. Fax: (520) 629-4738. E-mail: spherule{at}u.arizona.edu.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3467-3469, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00670-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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