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Antimicrobial Agents and Chemotherapy, October 2006, p. 3479-3484, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00210-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility among Pathogens Collected from Hospitalized Patients in the United States and In Vitro Activity of Tigecycline, a New Glycylcycline Antimicrobial

Ken B. Waites,1* Lynn B. Duffy,1 and Michael J. Dowzicky2

University of Alabama at Birmingham, Birmingham, Alabama,1 Wyeth Pharmaceuticals, Collegeville, Pennsylvania2

Received 17 February 2006/ Returned for modification 15 May 2006/ Accepted 23 July 2006

The activities of tigecycline and comparators against isolates collected from 76 U.S. centers between January 2004 and September 2005 were assessed. Tigecycline MIC90s were ≤2 µg/ml for Klebsiella pneumoniae, Klebsiella oxytoca, Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae, Serratia marcescens, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus agalactiae.

* Corresponding author. Mailing address: Section of Clinical Microbiology, University of Alabama at Birmingham, 619 South 19th Street, Birmingham, AL 35249. Phone: (205) 934-4960. Fax: (205) 975-4468. E-mail: waites{at}path.uab.edu.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3479-3484, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00210-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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