This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Queenan, A. M. Articles by Quinn, J. Search for Related Content PubMed PubMed Citation Articles by Queenan, A. M. Articles by Quinn, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2006, p. 3485-3487, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00363-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

SME-3, a Novel Member of the Serratia marcescens SME Family of Carbapenem-Hydrolyzing ß-Lactamases

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Raritan, New Jersey,¹ Loyola University Medical Center, Maywood, Illinois,² CIDRI, John H. Stroger Hospital of Cook County, Chicago, Illinois³

Received 24 March 2006/ Returned for modification 12 May 2006/ Accepted 14 July 2006

Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a ß-lactamase of the rare SME carbapenem-hydrolyzing family. SME-3 differed from SME-1 by a single amino acid substitution of tyrosine for histidine at position 105, but the two ß-lactamases displayed similar hydrolytic profiles.

This article has been cited by other articles:

• Walther-Rasmussen, J., Hoiby, N. (2007). Class A carbapenemases. J Antimicrob Chemother 60: 470-482 [Abstract] [Full Text]  
• Queenan, A. M., Shang, W., Kania, M., Page, M. G. P., Bush, K. (2007). Interactions of Ceftobiprole with {beta}-Lactamases from Molecular Classes A to D. Antimicrob. Agents Chemother. 51: 3089-3095 [Abstract] [Full Text]  
• Queenan, A. M., Bush, K. (2007). Carbapenemases: the Versatile {beta}-Lactamases. Clin. Microbiol. Rev. 20: 440-458 [Abstract] [Full Text]  
• Poirel, L., Wenger, A., Bille, J., Bernabeu, S., Naas, T., Nordmann, P. (2007). SME-2-Producing Serratia marcescens Isolate from Switzerland. Antimicrob. Agents Chemother. 51: 2282-2283 [Full Text]