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Antimicrobial Agents and Chemotherapy, October 2006, p. 3488-3491, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00606-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Protein O-Mannosyltransferase Isoforms Regulate Biofilm Formation in Candida albicans

Heidrun Peltroche-Llacsahuanga,1 Sophie Goyard,2 Christophe d'Enfert,2 Stephan K.-H. Prill,3 and Joachim F. Ernst3*

Institut für Medizinische Mikrobiologie, RWTH Aachen, Germany,1 Unité Postulante Biologie et Pathogénicité Fongiques, INRA USC 2019, Institut Pasteur, Paris, France,2 Institut für Mikrobiologie, Heinrich-Heine-Universität, Düsseldorf, Germany3

Received 17 May 2006/ Returned for modification 1 July 2006/ Accepted 15 July 2006

Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.

* Corresponding author. Mailing address: Institut for Mikrobiologie, Universitaetsstr. 1/26.12, 40225 Duesseldorf, Germany. Phone and fax: 49(211)811-5176. E-mail: joachim.ernst{at}uni-duesseldorf.de.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3488-3491, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00606-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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