This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cornet, M.
Right arrow Articles by Richard, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cornet, M.
Right arrow Articles by Richard, M. L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2006, p. 3492-3495, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00391-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Deletions of the Endocytic Components VPS28 and VPS32 in Candida albicans Lead to Echinocandin and Azole Hypersensitivity

Muriel Cornet,1,2 Claude Gaillardin,1* and Mathias L. Richard1

Microbiologie et Génétique Moléculaire, Institut National Agronomique Paris-Grignon, Institut National de la Recherche Agronomique UMR1238, Centre National de la Recherche Scientifique UMR2585, 78850 Thiverval-Grignon, France,1 Microbiologie, Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris Cedex 04, Assistance Publique-Hôpitaux de Paris, Université Paris V, Paris Descartes, Paris, France2

Received 30 March 2006/ Returned for modification 27 April 2006/ Accepted 15 July 2006

Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence. Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.

* Corresponding author. Mailing address: Laboratoire de Microbiologie et Génétique Moléculaire, INRA, CBAI, 78850 Thiverval-Grignon, France. Phone: 33 1 30 81 54 53. Fax: 33 1 30 81 54 57. E-mail: claude.gaillardin{at}grignon.inra.fr.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3492-3495, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00391-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chauhan, N., Kruppa, M., Calderone, R. (2007). The Ssk1p Response Regulator and Chk1p Histidine Kinase Mutants of Candida albicans Are Hypersensitive to Fluconazole and Voriconazole. Antimicrob. Agents Chemother. 51: 3747-3751 [Abstract] [Full Text]  
  • Thevissen, K., Ayscough, K. R., Aerts, A. M., Du, W., De Brucker, K., Meert, E. M. K., Ausma, J., Borgers, M., Cammue, B. P. A., Francois, I. E. J. A. (2007). Miconazole Induces Changes in Actin Cytoskeleton prior to Reactive Oxygen Species Induction in Yeast. J. Biol. Chem. 282: 21592-21597 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»