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Antimicrobial Agents and Chemotherapy, October 2006, p. 3492-3495, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00391-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Deletions of the Endocytic Components VPS28 and VPS32 in Candida albicans Lead to Echinocandin and Azole Hypersensitivity

Muriel Cornet,1,2 Claude Gaillardin,1* and Mathias L. Richard1

Microbiologie et Génétique Moléculaire, Institut National Agronomique Paris-Grignon, Institut National de la Recherche Agronomique UMR1238, Centre National de la Recherche Scientifique UMR2585, 78850 Thiverval-Grignon, France,1 Microbiologie, Hôtel-Dieu, 1 Place du Parvis Notre-Dame, 75181 Paris Cedex 04, Assistance Publique-Hôpitaux de Paris, Université Paris V, Paris Descartes, Paris, France2

Received 30 March 2006/ Returned for modification 27 April 2006/ Accepted 15 July 2006

Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence. Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.

* Corresponding author. Mailing address: Laboratoire de Microbiologie et Génétique Moléculaire, INRA, CBAI, 78850 Thiverval-Grignon, France. Phone: 33 1 30 81 54 53. Fax: 33 1 30 81 54 57. E-mail: claude.gaillardin{at}grignon.inra.fr.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3492-3495, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00391-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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