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Antimicrobial Agents and Chemotherapy, October 2006, p. 3501-3503, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00787-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis

Donald C. Sheppard,1* John R. Graybill,2 Laura K. Najvar,2 Lisa Y. Chiang,3 Thomas Doedt,3 William R. Kirkpatrick,2 Rosie Bocanegra,2 Ana C. Vallor,2 Thomas F. Patterson,2 and Scott G. Filler3,4

Department of Microbiology and Immunology, McGill University, Montreal, Canada,1 The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases San Antonio, Texas,2 Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California,3 The David Geffen School of Medicine at UCLA, Los Angeles, California4

Received 29 June 2006/ Accepted 1 July 2006

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

* Corresponding author. Mailing address: McGill University, Department of Microbiology and Immunology, Duff Medical Bldg., 3775 University St., Rm. 511, Montreal, H3A 2B4 Quebec, Canada. Phone: (514) 398-1759. Fax: (514) 398-7052. E-mail: donald.sheppard{at}mcgill.ca.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3501-3503, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00787-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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