AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sheppard, D. C.
Right arrow Articles by Filler, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sheppard, D. C.
Right arrow Articles by Filler, S. G.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, October 2006, p. 3501-3503, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00787-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis

Donald C. Sheppard,1* John R. Graybill,2 Laura K. Najvar,2 Lisa Y. Chiang,3 Thomas Doedt,3 William R. Kirkpatrick,2 Rosie Bocanegra,2 Ana C. Vallor,2 Thomas F. Patterson,2 and Scott G. Filler3,4

Department of Microbiology and Immunology, McGill University, Montreal, Canada,1 The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases San Antonio, Texas,2 Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California,3 The David Geffen School of Medicine at UCLA, Los Angeles, California4

Received 29 June 2006/ Accepted 1 July 2006

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.


* Corresponding author. Mailing address: McGill University, Department of Microbiology and Immunology, Duff Medical Bldg., 3775 University St., Rm. 511, Montreal, H3A 2B4 Quebec, Canada. Phone: (514) 398-1759. Fax: (514) 398-7052. E-mail: donald.sheppard{at}mcgill.ca.


Antimicrobial Agents and Chemotherapy, October 2006, p. 3501-3503, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00787-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.