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Antimicrobial Agents and Chemotherapy, November 2006, p. 3856-3860, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00082-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Hyaluronic Acid Binding Peptides Prevent Experimental Staphylococcal Wound Infection

Kathleen J. Zaleski,1* Tadeusz Kolodka,2 Colette Cywes-Bentley,1 Rachel M. McLoughlin,1 Mary L. Delaney,3 Bernard T. Charlton,2 Wendy Johnson,2 and Arthur O. Tzianabos1,4

Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,1 Cangene Corporation, Winnipeg, Manitoba R3T 5Y3, Canada,2 Department of Pathology, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,3 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 021154

Received 19 January 2006/ Returned for modification 22 February 2006/ Accepted 6 August 2006

Staphylococcus aureus is a major cause of surgical wound infections. The development of mechanisms of antimicrobial resistance by this and other bacterial pathogens has prompted the search for new approaches to treat infectious diseases. Hyaluronic acid binding peptides have been shown to modulate cellular trafficking during host responses and were assessed for their ability to treat and possibly prevent experimental surgical wound infections caused by S. aureus. Treatment with these peptides was highly efficacious in reducing the number of S. aureus cells at the wound site and ameliorated the inflammatory host response associated with these infections. These data suggest a novel approach for the treatment and prophylaxis of staphylococcal wound infections in the clinical setting.

* Corresponding author. Present address: Shire Pharmaceuticals, 700 Main Street, Cambridge, MA 02139. Phone: (617) 613-4068. Fax: (617) 613-4022. E-mail: kzaleski{at}shire.com.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3856-3860, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00082-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • McLoughlin, R. M., Lee, J. C., Kasper, D. L., Tzianabos, A. O. (2008). IFN-{gamma} Regulated Chemokine Production Determines the Outcome of Staphylococcus aureus Infection. J. Immunol. 181: 1323-1332 [Abstract] [Full Text]  


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