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Antimicrobial Agents and Chemotherapy, November 2006, p. 3882-3885, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00178-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Stephen Rittenhouse,* Sanjoy Biswas, John Broskey, Lynn McCloskey, Terrance Moore, Sandra Vasey, Joshua West, Magdalena Zalacain, Rimma Zonis, and David Payne

Department of Microbiology, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, Upper Providence, Pennsylvania

Received 9 February 2006/ Returned for modification 21 March 2006/ Accepted 10 July 2006

The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC90s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 µg/ml and 0.016 µg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.

* Corresponding author. Mailing address: Department of Microbiology Research, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Rd, Collegeville, PA 19426-0989. Phone: (610) 917-6287. Fax: (610) 917-7901. E-mail: Stephen_Rittenhouse{at}GSK.com.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3882-3885, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00178-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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