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Antimicrobial Agents and Chemotherapy, November 2006, p. 3882-3885, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00178-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Department of Microbiology, MMPD CEDD, GlaxoSmithKline Pharmaceuticals, Upper Providence, Pennsylvania

Received 9 February 2006/ Returned for modification 21 March 2006/ Accepted 10 July 2006

The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC₉₀s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 µg/ml and 0.016 µg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.

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