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Antimicrobial Agents and Chemotherapy, November 2006, p. 3897-3900, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00057-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Telithromycin-Nonsusceptible Clinical Isolates of Streptococcus pneumoniae from Europe

Adnan Al-Lahham,1,{dagger} Peter C. Appelbaum,2 Mark van der Linden,1 and Ralf René Reinert1*

Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital, Aachen, Germany,1 Hershey Medical Center, Hershey, Pennsylvania2

Received 13 January 2006/ Returned for modification 13 March 2006/ Accepted 30 July 2006

Telithromycin-nonsusceptible pneumococcal clinical isolates (n = 17) were analyzed for their antimicrobial susceptibility, macrolide resistance mechanisms, and genetic relatedness. All strains showed the erm(B) genotype and showed a wide range of combinations of macrolide resistance mechanisms. The predominant clone (n = 7) was serotype 14, sequence type 143.

* Corresponding author. Mailing address: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Pauwelsstr. 30, Aachen, Germany. Phone: 49 241 8089946. Fax: 49 241 8082483. E-mail: Reinert{at}rwth-aachen.de.

{dagger} Present address: German Jordanian University, School of Applied Medical Sciences, Amman, Jordan.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3897-3900, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00057-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wolter, N., Smith, A. M., Low, D. E., Klugman, K. P. (2007). High-Level Telithromycin Resistance in a Clinical Isolate of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51: 1092-1095 [Abstract] [Full Text]  


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