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In Vitro Killing of Nosocomial Pathogens by Acid and Acidified Nitrite

Department of Medicine, University Hospitals of Cleveland, Cleveland, Ohio,¹ Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio²

Received 23 November 2005/ Returned for modification 9 March 2006/ Accepted 2 July 2006

Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae, Staphylococcus aureus, and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.

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