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Antimicrobial Agents and Chemotherapy, November 2006, p. 3905-3907, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00522-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Suppression of Gastric Acid Production by Proton Pump Inhibitor Treatment Facilitates Colonization of the Large Intestine by Vancomycin-Resistant Enterococcus spp. and Klebsiella pneumoniae in Clindamycin-Treated Mice

Research Service, Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio 44106,¹ University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106²

Received 27 April 2006/ Returned for modification 6 August 2006/ Accepted 17 August 2006

Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.

Published ahead of print on 28 August 2006.