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Antimicrobial Agents and Chemotherapy, November 2006, p. 3908-3913, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00639-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Antianaerobic Activity of DX-619, a New Des-Fluoro(6) Quinolone

Kaori Tanaka,* Hiroshige Mikamo, Ken'ichi Nakao, and Kunitomo Watanabe

Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan

Received 24 May 2006/ Returned for modification 30 June 2006/ Accepted 28 July 2006

The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC50s/MIC90s of ≤0.03 to 0.25/≤0.03 to 1 µg/ml, respectively. DX-619 was also active against imipenem-resistant Bacteroides spp., with MIC50s/MIC90s of 0.25/1 µg/ml, respectively.

* Corresponding author. Mailing address: Division of Anaerobe Research, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. Phone: 81-58-230-6553. Fax: 81-58-230-6551. E-mail: kktb{at}gifu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3908-3913, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00639-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wexler, H. M. (2007). Bacteroides: the Good, the Bad, and the Nitty-Gritty. Clin. Microbiol. Rev. 20: 593-621 [Abstract] [Full Text]  


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