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Antimicrobial Agents and Chemotherapy, November 2006, p. 3917-3919, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00747-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Basis for Enhanced Activity of Posaconazole against Absidia corymbifera and Rhizopus oryzae{triangledown}

Andrew S. Chau, Guodong Chen, Paul M. McNicholas,* and Paul A. Mann

Schering-Plough Research Institute, 2015 Galloping Hill Road, 4700, Kenilworth, New Jersey 07033

Received 19 June 2006/ Returned for modification 15 July 2006/ Accepted 30 August 2006

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.

* Corresponding author. Mailing address: Schering-Plough Research Institute, 2015 Galloping Hill Road, 4700, Kenilworth, NJ 07033. Phone: (908) 740-7644. Fax: (908) 740-3918. E-mail: paul.mcnicholas{at}spcorp.com.

{triangledown} Published ahead of print on 11 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3917-3919, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00747-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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