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Antimicrobial Agents and Chemotherapy, November 2006, p. 3920-3922, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00223-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Novel Streptomycin Resistance Gene from Mycobacterium fortuitum{triangledown}

Santiago Ramón-García, Isabel Otal, Carlos Martín, Rafael Gómez-Lus, and José A. Aínsa*

Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, 50009 Zaragoza, Spain

Received 21 February 2006/ Returned for modification 2 June 2006/ Accepted 30 August 2006

We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.

* Corresponding author. Mailing address: Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, C/ Domingo Miral s/n, 50009-Zaragoza, Spain. Phone: 34-976-762420. Fax: 34-976-762604. E-mail: ainsa{at}unizar.es.

{triangledown} Published ahead of print on 5 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3920-3922, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00223-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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