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Antimicrobial Agents and Chemotherapy, November 2006, p. 3923-3925, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00652-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Tritrpticin Alone and in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa{triangledown}

Oscar Cirioni, Andrea Giacometti,* Carmela Silvestri, Agnese Della Vittoria, Alberto Licci, Alessandra Riva, and Giorgio Scalise

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche-Ospedali Riuniti Ancona, Ancona, Italy

Received 30 May 2006/ Returned for modification 17 July 2006/ Accepted 18 August 2006

The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa. The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 µM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and ß-lactams.

* Corresponding author. Mailing address: Clinica Malattie Infettive, Ospedali Riuniti Ancona, via Conca 71, I-60020 Ancona, Italy. Phone: 39 071 5963467. Fax: 39 071 5963468. E-mail: a.giacometti{at}univpm.it.

{triangledown} Published ahead of print on 28 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3923-3925, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00652-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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