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Antimicrobial Agents and Chemotherapy, November 2006, p. 3926-3928, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00538-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Pharmacodynamics of Anidulafungin and Caspofungin against Candida glabrata Isolates, Including Strains with Decreased Caspofungin Susceptibility{triangledown}

Jason Cota,1,2 Michael Carden,2 John R. Graybill,2 Laura K. Najvar,2 David S. Burgess,1,2 and Nathan P. Wiederhold1,2*

The University of Texas at Austin College of Pharmacy, Austin, Texas,1 The University of Texas Health Science Center at San Antonio, San Antonio, Texas2

Received 1 May 2006/ Returned for modification 19 June 2006/ Accepted 14 August 2006

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC50 values), and IC90 values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

* Corresponding author. Mailing address: University of Texas at Austin College of Pharmacy, UTHSCSA, Clinical Pharmacy, MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-8340. Fax: (210) 567-8328. E-mail: wiederholdn{at}uthscsa.edu.

{triangledown} Published ahead of print on 28 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3926-3928, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00538-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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