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Antimicrobial Agents and Chemotherapy, November 2006, p. 3934-3938, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00732-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Prevalence of Mutations Associated with Higher Levels of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Isolates from Car Nicobar Island and Assam, India{triangledown}

Anwar Ahmed,1 Vanshika Lumb,1 Manoj K. Das,2 Vas Dev,2 Wajihullah,3 and Yagya D. Sharma1*

Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029,1 National Institute of Malaria Research, 22 Shamnath Marg, Delhi 110054,2 Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India3

Received 14 June 2006/ Returned for modification 25 August 2006/ Accepted 5 September 2006

To assess sulfadoxine and pyrimethamine resistance (SPR), we describe here the dihydropteroate synthetase (DHPS) mutations among the Plasmodium falciparum isolates in which dihydrofolate reductase (DHFR) mutations had recently been described by us (A. Ahmed, M. K. Das, V. Dev, M. A. Saifi, Wajihullah, and Y. D. Sharma, Antimicrob. Agents Chemother. 50:1546-1549, 2006). A majority of isolates from Car Nicobar island showed double DHPS mutations, whereas a majority of isolates from Uttar Pradesh (U.P.) and Assam contained the wild-type DHPS. Based on DHFR-DHPS mutations, the expected level of SPR was lowest in U.P., higher in Assam, and highest in Car Nicobar, suggesting that a region-wise drug policy is needed in India.

* Corresponding author. Mailing address: Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Phone: 91-11-26588145. Fax: 91-11-26589286. E-mail: ydsharma_aiims{at}yahoo.com.

{triangledown} Published ahead of print on 18 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3934-3938, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00732-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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