This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmed, A.
Right arrow Articles by Sharma, Y. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmed, A.
Right arrow Articles by Sharma, Y. D.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2006, p. 3934-3938, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00732-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Prevalence of Mutations Associated with Higher Levels of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Isolates from Car Nicobar Island and Assam, India{triangledown}

Anwar Ahmed,1 Vanshika Lumb,1 Manoj K. Das,2 Vas Dev,2 Wajihullah,3 and Yagya D. Sharma1*

Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029,1 National Institute of Malaria Research, 22 Shamnath Marg, Delhi 110054,2 Department of Zoology, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India3

Received 14 June 2006/ Returned for modification 25 August 2006/ Accepted 5 September 2006

To assess sulfadoxine and pyrimethamine resistance (SPR), we describe here the dihydropteroate synthetase (DHPS) mutations among the Plasmodium falciparum isolates in which dihydrofolate reductase (DHFR) mutations had recently been described by us (A. Ahmed, M. K. Das, V. Dev, M. A. Saifi, Wajihullah, and Y. D. Sharma, Antimicrob. Agents Chemother. 50:1546-1549, 2006). A majority of isolates from Car Nicobar island showed double DHPS mutations, whereas a majority of isolates from Uttar Pradesh (U.P.) and Assam contained the wild-type DHPS. Based on DHFR-DHPS mutations, the expected level of SPR was lowest in U.P., higher in Assam, and highest in Car Nicobar, suggesting that a region-wise drug policy is needed in India.

* Corresponding author. Mailing address: Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. Phone: 91-11-26588145. Fax: 91-11-26589286. E-mail: ydsharma_aiims{at}yahoo.com.

{triangledown} Published ahead of print on 18 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3934-3938, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00732-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vinayak, S., Alam, M. T., Upadhyay, M., Das, M. K., Dev, V., Singh, N., Dash, A. P., Sharma, Y. D. (2007). Extensive Genetic Diversity in the Plasmodium falciparum Na+/H+ Exchanger 1 Transporter Protein Implicated in Quinine Resistance. Antimicrob. Agents Chemother. 51: 4508-4511 [Abstract] [Full Text]  
  • Alam, M. T., Bora, H., Bharti, P. K., Saifi, M. A., Das, M. K., Dev, V., Kumar, A., Singh, N., Dash, A. P., Das, B., Wajihullah, , Sharma, Y. D. (2007). Similar Trends of Pyrimethamine Resistance-Associated Mutations in Plasmodium vivax and P. falciparum. Antimicrob. Agents Chemother. 51: 857-863 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»