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Antimicrobial Agents and Chemotherapy, November 2006, p. 3956-3958, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00724-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effect of Ceftobiprole against 12 Gram-Positive Organisms

G. A. Pankuch and P. C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 12 June 2006/ Returned for modification 1 July 2006/ Accepted 8 July 2006

The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of ceftobiprole were determined for 12 gram-positive organisms. Pneumococcal, staphylococcal, and enterococcal PAEs were 1.4 to 3.1 h, 0 to 1.8 h, and 0 to 0.9 h, respectively. The PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 4.8 to >10.3 h, 1.5 to 9.6 h, and 3.8 to >10.7 h, respectively.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3956-3958, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00724-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pankuch, G. A., Appelbaum, P. C. (2009). Postantibiotic Effect of Ceftaroline against Gram-Positive Organisms. Antimicrob. Agents Chemother. 53: 4537-4539 [Abstract] [Full Text]  
  • Pankuch, G. A., Appelbaum, P. C. (2009). Postantibiotic Effects of Telavancin against 16 Gram-Positive Organisms. Antimicrob. Agents Chemother. 53: 1275-1277 [Abstract] [Full Text]  
  • Pankuch, G. A., Appelbaum, P. C. (2009). Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms. Antimicrob. Agents Chemother. 53: 782-784 [Abstract] [Full Text]  
  • Anderson, S. D, Gums, J. G (2008). Ceftobiprole: An Extended-Spectrum Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin. The Annals of Pharmacotherapy 42: 806-816 [Abstract] [Full Text]  


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