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Antimicrobial Agents and Chemotherapy, November 2006, p. 3959-3962, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Ceftobiprole against Aerobic and Anaerobic Strains Isolated from Diabetic Foot Infections{triangledown}

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 and Helen T. Fernandez1

The R. M. Alden Research Laboratory, Santa Monica, California 90404,1 the UCLA School of Medicine, Los Angeles, California 900732

Received 11 June 2006/ Returned for modification 6 August 2006/ Accepted 8 September 2006

Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (µg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevotii, 0.125; Finegoldia magna, 0.5; Peptoniphilus asaccharolyticus, 1; Peptostreptococcus anaerobius, 4; Escherichia coli and Enterobacter species, 0.125; Klebsiella species, 2; and Pseudomonas aeruginosa, 8.

* Corresponding author. Mailing address: R. M. Alden Research Laboratory, 2021 Santa Monica Blvd, #740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com.

{triangledown} Published ahead of print on 18 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3959-3962, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00722-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Anderson, S. D, Gums, J. G (2008). Ceftobiprole: An Extended-Spectrum Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin. The Annals of Pharmacotherapy 42: 806-816 [Abstract] [Full Text]  
  • Pillar, C. M., Aranza, M. K., Shah, D., Sahm, D. F. (2008). In vitro activity profile of ceftobiprole, an anti-MRSA cephalosporin, against recent Gram-positive and Gram-negative isolates of European origin. J Antimicrob Chemother 61: 595-602 [Abstract] [Full Text]  
  • Frank, K. L., del Pozo, J. L., Patel, R. (2008). From Clinical Microbiology to Infection Pathogenesis: How Daring To Be Different Works for Staphylococcus lugdunensis. Clin. Microbiol. Rev. 21: 111-133 [Abstract] [Full Text]  
  • Arias, C. A., Singh, K. V., Panesso, D., Murray, B. E. (2007). Time-Kill and Synergism Studies of Ceftobiprole against Enterococcus faecalis, Including {beta}-Lactamase-Producing and Vancomycin-Resistant Isolates. Antimicrob. Agents Chemother. 51: 2043-2047 [Abstract] [Full Text]  


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