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Antimicrobial Agents and Chemotherapy, November 2006, p. 3963-3965, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00393-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy{triangledown}

Chiatogu Onyewu,3 Natalie A. Afshari,4* and Joseph Heitman1,2,3*

Departments of Molecular Genetics and Microbiology,1 Medicine,2 Pharmacology and Cancer Biology,3 Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 277104

Received 30 March 2006/ Returned for modification 13 May 2006/ Accepted 15 August 2006

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

* Corresponding author. Mailing address for N. A. Afshari: Department of Ophthalmology, Wadsworth Bldg., Box 3802, Erwin Road, Duke University Eye Center, Durham, NC 27710. Phone: (919) 684-3799. Fax: (919) 681-7661. E-mail: afsha003{at}mc.duke.edu. Mailing address for J. Heitman: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Drive, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu.

{triangledown} Published ahead of print on 21 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3963-3965, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00393-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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