This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2006, p. 3963-3965, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00393-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy{triangledown}

Chiatogu Onyewu,3 Natalie A. Afshari,4* and Joseph Heitman1,2,3*

Departments of Molecular Genetics and Microbiology,1 Medicine,2 Pharmacology and Cancer Biology,3 Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 277104

Received 30 March 2006/ Returned for modification 13 May 2006/ Accepted 15 August 2006

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

* Corresponding author. Mailing address for N. A. Afshari: Department of Ophthalmology, Wadsworth Bldg., Box 3802, Erwin Road, Duke University Eye Center, Durham, NC 27710. Phone: (919) 684-3799. Fax: (919) 681-7661. E-mail: afsha003{at}mc.duke.edu. Mailing address for J. Heitman: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Drive, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu.

{triangledown} Published ahead of print on 21 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3963-3965, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00393-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dannaoui, E., Schwarz, P., Lortholary, O. (2009). In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrob. Agents Chemother. 53: 3549-3551 [Abstract] [Full Text]  
  • Semighini, C. P., Heitman, J. (2009). Dynamic duo takes down fungal villains. Proc. Natl. Acad. Sci. USA 106: 2971-2972 [Full Text]  
  • Uppuluri, P., Nett, J., Heitman, J., Andes, D. (2008). Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms. Antimicrob. Agents Chemother. 52: 1127-1132 [Abstract] [Full Text]  
  • Onyewu, C., Eads, E., Schell, W. A., Perfect, J. R., Ullmann, Y., Kaufman, G., Horwitz, B. A., Berdicevsky, I., Heitman, J. (2007). Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors against Trichophyton mentagrophytes In Vitro and in a Human Skin Infection Model. Antimicrob. Agents Chemother. 51: 3743-3746 [Abstract] [Full Text]  
  • Fan, W., Idnurm, A., Breger, J., Mylonakis, E., Heitman, J. (2007). Eca1, a Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase, Is Involved in Stress Tolerance and Virulence in Cryptococcus neoformans. Infect. Immun. 75: 3394-3405 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»