This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Co, E.-M. A.
Right arrow Articles by Schiller, N. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Co, E.-M. A.
Right arrow Articles by Schiller, N. L.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, December 2006, p. 4174-4176, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00759-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Resistance Mechanisms in an In Vitro-Selected Amoxicillin-Resistant Strain of Helicobacter pylori{triangledown}

Edgie-Mark A. Co and Neal L. Schiller*

Biomedical Sciences Division, University of California, Riverside, Riverside, California 92521

Received 22 June 2006/ Returned for modification 25 August 2006/ Accepted 14 September 2006

We investigated the ß-lactam resistance mechanism(s) of an in vitro-selected amoxicillin-resistant Helicobacter pylori strain (AmoxR). Our results demonstrated that resistance is due to a combination of amino acid substitutions in penicillin binding protein 1 (PBP1), HopB, and HopC identified in AmoxR, resulting in decreased affinity of PBP1 for amoxicillin and decreased accumulation of penicillin.

* Corresponding author. Mailing address: Biomedical Sciences Division, University of California, Riverside, Riverside, CA 92521-0121. Phone: (951) 827-4535. Fax: (951) 827-5504. E-mail: neal.schiller{at}ucr.edu.

{triangledown} Published ahead of print on 25 September 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4174-4176, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00759-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rimbara, E., Noguchi, N., Kawai, T., Sasatsu, M. (2008). Mutations in penicillin-binding proteins 1, 2 and 3 are responsible for amoxicillin resistance in Helicobacter pylori. J Antimicrob Chemother 61: 995-998 [Abstract] [Full Text]  
  • Matteo, M. J., Granados, G., Olmos, M., Wonaga, A., Catalano, M. (2008). Helicobacter pylori amoxicillin heteroresistance due to point mutations in PBP-1A in isogenic isolates. J Antimicrob Chemother 61: 474-477 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»