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Antimicrobial Agents and Chemotherapy, December 2006, p. 4182-4185, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00714-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

High Prevalence of the K65R Mutation in Human Immunodeficiency Virus Type 1 Subtype C Isolates from Infected Patients in Botswana Treated with Didanosine-Based Regimens{triangledown}

Florence Doualla-Bell,1,2 Ava Avalos,3 Bluma Brenner,2 Tendani Gaolathe,1,3 Madisa Mine,1 Simani Gaseitsiwe,1 Maureen Oliveira,2 Daniella Moisi,2 Ndwapi Ndwapi,1 Howard Moffat,3 Max Essex,1,4 and Mark A. Wainberg2*

Botswana-Harvard School of Public Health AIDS Initiative Partnership for HIV Research and Education, Gaborone, Botswana,1 McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada,2 Infectious Disease Care Clinic, Princess Marina Hospital, Gaborone, Botswana,3 Harvard School of Public Health, Boston, Massachusetts4

Received 8 June 2006/ Returned for modification 24 July 2006/ Accepted 21 September 2006

We analyzed the reverse transcriptase genotypes of human immunodeficiency virus type 1 subtype C viruses isolated from 23 patients in Botswana treated with didanosine-based regimens. The K65R mutation was selected either alone or together with the Q151M, S68G, or F116Y substitution in viruses from seven such individuals. The results of in vitro passage experiments were consistent with an apparent increased propensity of subtype C viruses to develop the K65R substitution.

* Corresponding author. Mailing address: McGill AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Chemin Côte-Ste-Catherine, Montreal (Quebec) H3T 1E2, Canada. Phone: (514) 340 8260. Fax: (514) 340 7537. E-mail: mark.wainberg{at}mcgill.ca.

{triangledown} Published ahead of print on 2 October 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4182-4185, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00714-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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