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Antimicrobial Agents and Chemotherapy, December 2006, p. 4195-4197, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00678-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparative Bactericidal Activities of Daptomycin and Vancomycin against Glycopeptide-Intermediate Staphylococcus aureus (GISA) and Heterogeneous GISA Isolates{triangledown}

Mandy Wootton,1,2* Alasdair P. MacGowan,2 and Timothy R. Walsh1,{dagger}

Bristol Centre for Antimicrobial Research and Evaluation (BCARE), Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, United Kingdom,1 BCARE, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, United Kingdom2

Received 2 June 2006/ Returned for modification 7 July 2006/ Accepted 6 October 2006

Staphylococcus aureus strains from the U.S. SENTRY Antimicrobial Surveillance Program, 2002-2003, glycopeptide-intermediate S. aureus (GISA) strains, and heterogeneous GISA (hGISA) strains were used to compare bactericidal activities of daptomycin and vancomycin using MICs and minimum bactericidal concentrations. Glycopeptide-susceptible S. aureus and hGISA strains were further studied by using time-kill curves. For all isolates, the daptomycin MIC50 and MIC90 are four times lower and the log drops in viable counts at 6 h and 24 h are significantly greater than those for vancomycin.

* Corresponding author. Present address: Specialist Antimicrobial Chemotherapy Unit, NPHS Microbiology Cardiff, University Hospital Wales, Heath Park, Cardiff CF14 4XW, United Kingdom. Phone: 44 02920 746581. Fax: 44 02920 744130. E-mail: mandy.wootton{at}nphs.wales.nhs.uk.

{triangledown} Published ahead of print on 16 October 2006.

{dagger} Present address: School of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XW, United Kingdom.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4195-4197, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00678-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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