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Antimicrobial Agents and Chemotherapy, December 2006, p. 4198-4201, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00663-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Emergence of Multidrug-Resistant Klebsiella pneumoniae Isolates Producing VIM-4 Metallo-ß-Lactamase, CTX-M-15 Extended-Spectrum ß-Lactamase, and CMY-4 AmpC ß-Lactamase in a Tunisian University Hospital{triangledown}

Sonia Ktari,1 Guillaume Arlet,2* Basma Mnif,1 Valérie Gautier,2 Fouzia Mahjoubi,1 Mounir Ben Jmeaa,3 Mounir Bouaziz,4 and Adnane Hammami1

Laboratoire de Microbiologie,1 Service des Maladies Infectieuses,3 Service de Réanimation, CHU Habib Bourguiba, Sfax, Tunisie,4 Université Pierre et Marie Curie, Faculté de Médecine, Laboratoire de Bactériologie, UPRES EA No. 2392, Paris, France2

Received 31 May 2006/ Returned for modification 28 July 2006/ Accepted 20 September 2006

Klebsiella pneumoniae clinical isolates resistant to carbapenems were recovered from 11 patients in the hospital of Sfax, Tunisia. The isolates were closely related as shown by pulsed-field gel electrophoresis, and they produced VIM-4 metallo-enzyme, CTX-M-15 extended-spectrum ß-lactamase, and CMY-4 AmpC enzyme. The blaVIM-4 gene is part of a class 1 integron.

* Corresponding author. Mailing address: Service de Bactériologie-Hygiène, Hôpital Tenon, 4 rue de la Chine, 75970 Paris Cedex 20, France. Phone: 33 1 56 01 70 18. Fax: 33 1 56 01 61 08. E-mail: guillaume.arlet{at}tnn.aphp.fr.

{triangledown} Published ahead of print on 2 October 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4198-4201, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00663-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Queenan, A. M., Bush, K. (2007). Carbapenemases: the Versatile {beta}-Lactamases. Clin. Microbiol. Rev. 20: 440-458 [Abstract] [Full Text]  


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