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Antimicrobial Agents and Chemotherapy, December 2006, p. 4202-4205, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00485-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans{triangledown}

J. C. Bowman,1* G. K. Abruzzo,1 A. M. Flattery,1 C. J. Gill,1 E. J. Hickey,1 M. J. Hsu,1 J. Nielsen Kahn,1 P. A. Liberator,1 A. S. Misura,1 B. A. Pelak,1 T. C. Wang,2 and C. M. Douglas1

Departments of Infectious Disease,1 Biometrics Research, Merck Research Laboratories, Rahway, NJ 07065-09002

Received 19 April 2006/ Returned for modification 2 July 2006/ Accepted 14 September 2006

The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-ß-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

* Corresponding author. Mailing address: Department of Infectious Disease Research, Merck Research Laboratories, RY80Y-260, P.O. Box 2000, Rahway, NJ 07065-0900. Phone: (732) 594-1946. Fax: (732) 594-6708. E-mail: joel_bowman{at}merck.com.

{triangledown} Published ahead of print on 2 October 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4202-4205, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00485-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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