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Antimicrobial Agents and Chemotherapy, February 2006, p. 744-747, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.744-747.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inhibition of Candida parapsilosis Mitochondrial Respiratory Pathways Enhances Susceptibility to Caspofungin

Georgios Chamilos,1 Russell E. Lewis,1,2 and Dimitrios P. Kontoyiannis1,2*

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas,1 University of Houston College of Pharmacy, Houston, Texas2

Received 11 August 2005/ Returned for modification 10 October 2005/ Accepted 19 October 2005

Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (≥2- µg/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.

* Corresponding author. Mailing address: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org.

Antimicrobial Agents and Chemotherapy, February 2006, p. 744-747, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.744-747.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yan, L., Li, M., Cao, Y., Gao, P., Cao, Y., Wang, Y., Jiang, Y. (2009). The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility. J Antimicrob Chemother 64: 764-773 [Abstract] [Full Text]  


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