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Antimicrobial Agents and Chemotherapy, February 2006, p. 748-751, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.748-751.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efficacy of Quinolones against Secondary Pneumococcal Pneumonia after Influenza Virus Infection in Mice

Katsuhiko Hayashi, Shin-etsu Kadowaki,* Masaya Takei, and Hideyuki Fukuda

Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Nogi, Shimotsuga, Tochigi 329-0114, Japan

Received 8 July 2005/ Returned for modification 18 July 2005/ Accepted 13 November 2005

We established a mouse model of secondary pneumococcal pneumonia after influenza virus infection and investigated the efficacy of several quinolones against pneumonia in this model. Gatifloxacin exhibited the highest efficacy among the quinolones examined and is probably useful for the treatment of secondary bacterial pneumonia.

* Corresponding author. Mailing address: Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd., 2399-1, Nogi, Shimotsuga, Tochigi 329-0114, Japan. Phone: 81-280-56-2201. Fax: 81-280-57-1293. E-mail: shinetsu.kadowaki{at}mb.kyorin-pharm.co.jp.

Antimicrobial Agents and Chemotherapy, February 2006, p. 748-751, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.748-751.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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