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Antimicrobial Agents and Chemotherapy, February 2006, p. 752-755, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.752-755.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Potentiation of Catechin Gallate-Mediated Sensitization of Staphylococcus aureus to Oxacillin by Nongalloylated Catechins{dagger}

Paul D. Stapleton,1 Saroj Shah,1 Yukihiko Hara,2 and Peter W. Taylor1*

Microbiology Group, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom,1 Mitsui Norin Co., Ltd., 3-1-20 Nihombashi Muromachi, Chuo-Ku, Tokyo 103, Japan2

Received 22 September 2005/ Returned for modification 8 November 2005/ Accepted 9 November 2005

(–)–Epicatechin gallate (ECg) and (–)–epigallocatechin gallate (EGCg) reduce oxacillin resistance in mecA-containing strains of Staphylococcus aureus. Their binding to staphylococcal cells is enhanced by the nongalloyl analogues (–)–epicatechin (EC) and (–)–epigallocatechin (EGC). EC and EGC significantly increased the capacity of ECg and EGCg to reduce levels of staphylococcal oxacillin resistance.

* Corresponding author. Mailing address: Department of Pharmaceutics, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom. Phone and fax: 44 20 7753 5867. E-mail: peter.taylor{at}ulsop.ac.uk.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, February 2006, p. 752-755, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.752-755.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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