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Antimicrobial Agents and Chemotherapy, February 2006, p. 759-761, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.759-761.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection

David A. Kocisko,1* Winslow S. Caughey,1 Richard E. Race,1 Grant Roper,2 Byron Caughey,1 and John D. Morrey2

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana,1 Institute for Antiviral Research, Animal, Dairy, and Veterinary Sciences Department, Utah State University, Logan, Utah2

Received 8 September 2005/ Returned for modification 14 November 2005/ Accepted 23 November 2005

Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.

* Corresponding author. Mailing address: Rocky Mountain Laboratories, 903 S. 4th Street, Hamilton, MT 59840. Phone: (406) 375-9692. Fax: (406) 363-9286. E-mail: DKocisko{at}niaid.nih.gov.

Antimicrobial Agents and Chemotherapy, February 2006, p. 759-761, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.759-761.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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