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Antimicrobial Agents and Chemotherapy, February 2006, p. 765-769, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.765-769.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes

Klaudia Kosowska-Shick, Catherine Clark, Kim Credito, Pamela McGhee, Bonifacio Dewasse, Tatiana Bogdanovich, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 2 September 2005/ Returned for modification 16 October 2005/ Accepted 7 November 2005

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, February 2006, p. 765-769, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.765-769.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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