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Antimicrobial Agents and Chemotherapy, February 2006, p. 788-790, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.788-790.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Tissue Penetration of Telavancin after Intravenous Administration in Healthy Subjects

Heather K. Sun,1 Kenneth Duchin,2 Charles H. Nightingale,1 Jeng-Pyng Shaw,2 Julie Seroogy,2 and David P. Nicolau1,3*

Center for Anti-Infective Research and Development,1 Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut 06102,3 Theravance, Inc., South San Francisco, California 940802

Received 1 August 2005/ Returned for modification 20 August 2005/ Accepted 24 November 2005

The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections.

* Corresponding author. Mailing address: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102. Phone: (860) 545-3941. Fax: (860) 545-3992. E-mail: dnicola{at}harthosp.org.

Antimicrobial Agents and Chemotherapy, February 2006, p. 788-790, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.788-790.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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