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Antimicrobial Agents and Chemotherapy, February 2006, p. 803-805, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.803-805.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Trematocidal Activity of Praziquantel and Artemisinin Derivatives: In Vitro and In Vivo Investigations with Adult Echinostoma caproni

Jennifer Keiser,1* Reto Brun,1 Bernard Fried,2 and Jürg Utzinger1

Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland,1 Department of Biology, Lafayette College, Easton, Pennsylvania 180422

Received 24 September 2005/ Returned for modification 5 November 2005/ Accepted 14 November 2005

We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.

* Corresponding author. Mailing address: Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. Phone: 41 61 284-8218. Fax: 41 61 284-8105. E-mail: jennifer.keiser{at}unibas.ch.

Antimicrobial Agents and Chemotherapy, February 2006, p. 803-805, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.803-805.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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