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Antimicrobial Agents and Chemotherapy, February 2006, p. 806-809, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.806-809.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Bactericidal Activity of Human ß-Defensin 3 against Multidrug-Resistant Nosocomial Strains

Giuseppantonio Maisetta, Giovanna Batoni,* Semih Esin, Walter Florio, Daria Bottai, Flavia Favilli, and Mario Campa

Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy

Received 4 August 2005/ Returned for modification 13 September 2005/ Accepted 14 November 2005

The antimicrobial activity of human ß-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.

* Corresponding author. Mailing address: Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Via San Zeno 35-39, 56127, Pisa, Italy. Phone: 39-050-2213694. Fax: 39-050-2213771. E-mail: batoni{at}biomed.unipi.it.

Antimicrobial Agents and Chemotherapy, February 2006, p. 806-809, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.806-809.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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