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Antimicrobial Agents and Chemotherapy, February 2006, p. 810-812, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.810-812.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus

Inshad Ali Khan,* Zahid Mehmood Mirza, Ashwani Kumar, Vijeshwar Verma, and Ghulam Nabi Qazi

Biotechnology Division, Regional Research Laboratory, Jammu Tawi 180001, India

Received 20 September 2005/ Returned for modification 13 October 2005/ Accepted 28 November 2005

Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.

* Corresponding author. Mailing address: Biotechnology Division, Regional Research Laboratory, Canal Road, Jammu Tawi, 180001 India. Phone: 91-191-2572002. Fax: 91-191-2543829. E-mail: inshad{at}rrljammu.org.

Antimicrobial Agents and Chemotherapy, February 2006, p. 810-812, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.810-812.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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