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Antimicrobial Agents and Chemotherapy, February 2006, p. 817-818, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.817-818.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Streptococcus pyogenes Isolates with High-Level Macrolide Resistance and Reduced Susceptibility to Telithromycin Associated with 23S rRNA Mutations

David J. Farrell,1 Jemma Shackcloth,1 Karen A. Barbadora,2 and Michael D. Green2*

GR Micro Limited, London, United Kingdom,1 Division of Pediatric Allergy, Immunology, and Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania2

Received 31 August 2005/ Returned for modification 28 September 2005/ Accepted 9 November 2005

Seven high-level macrolide-resistant Streptococcus pyogenes isolates had reduced activity to telithromycin but were negative for methylation and efflux genes. All were of the constitutive phenotype, were clonally related (emm type 12 and MLST type 36), and had identical dual mutations (A2058G and U2166C) in domain V of 23S rRNA.

* Corresponding author. Mailing address: Medical and Molecular Microbiology, GR Micro Limited, 7-9 William Road, London, NW1 3ER, United Kingdom. Phone: 44 (0)20 73887320. Fax: 44 (0) 20 73887324. E-mail: D.Farrell{at}grmicro.co.uk.

Antimicrobial Agents and Chemotherapy, February 2006, p. 817-818, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.817-818.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Robinson, D. A., Sutcliffe, J. A., Tewodros, W., Manoharan, A., Bessen, D. E. (2006). Evolution and global dissemination of macrolide-resistant group a streptococci.. Antimicrob. Agents Chemother. 50: 2903-2911 [Abstract] [Full Text]  
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