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Antimicrobial Agents and Chemotherapy, March 2006, p. 1063-1066, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1063-1066.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Inactivation of Herpes Simplex Virus Clinical Isolates by Using a Combination Microbicide

Institute for Basic Research, 1050 Forest Hill Road, Staten Island, New York 10314,¹ Laboratory No. 520, Magee Womens Research Institute School of Pharmacy, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213,² Department of Molecular Genetics and Biochemistry, BST 1240, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261,³ Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh/Magee Womens Hospital, 300 Halket Street, Pittsburgh, Pennsylvania 15213⁴

Received 20 July 2005/ Returned for modification 1 September 2005/ Accepted 3 December 2005

A combination microbicide using the lipid-ether 1-0-octyl-sn-glycerol (OG) (3 mM) and peptide LSA5 (9 µM) synergistically inactivated six clinical isolates of herpes simplex virus type 2 (HSV-2) by 30- to 100-fold and five of six HSV-1 isolates by 10-fold more than the sum of OG and LSA5 used individually within 30 min. OG plus LSA5 inactivated all HSV clinical isolates by 1,000-fold in 10 to 40 min.