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Antimicrobial Agents and Chemotherapy, March 2006, p. 1075-1078, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1075-1078.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Isoniazid Resistance in Mycobacterium tuberculosis: Identification of a Novel Mutation in inhA

E. T. Y. Leung, P. L. Ho, K. Y. Yuen, W. L. Woo, T. H. Lam, R. Y. Kao, W. H. Seto, and W. C. Yam*

Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China

Received 22 September 2005/ Returned for modification 25 October 2005/ Accepted 8 December 2005

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp –15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

* Corresponding author. Mailing address: Department of Microbiology, 4/F, University Pathology Bldg., Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, China. Phone: 852 2855 4821. Fax: 852 2855 1241. E-mail: wcyam{at}hkucc.hku.hk.

Antimicrobial Agents and Chemotherapy, March 2006, p. 1075-1078, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1075-1078.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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