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Antimicrobial Agents and Chemotherapy, March 2006, p. 1079-1082, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1079-1082.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

Longzhu Cui,1,2* Eiji Tominaga,2 Hui-min Neoh,1 and Keiichi Hiramatsu1,2

Department of Bacteriology,1 Department of Infection Control Science, Juntendo University, 2-1-1 Bunkyo-Ku, Tokyo, Japan 113-84212

Received 17 August 2005/ Returned for modification 18 October 2005/ Accepted 27 December 2005

We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

* Corresponding author. Mailing address: Department of Bacteriology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan 113-8421. Phone: (81 3) 5802-1041. Fax: (81 3) 5684-7830. E-mail: longzhu{at}med.juntendo.ac.jp.

Antimicrobial Agents and Chemotherapy, March 2006, p. 1079-1082, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1079-1082.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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