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Antimicrobial Agents and Chemotherapy, March 2006, p. 1096-1099, Vol. 50, No. 3
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.3.1096-1099.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Potent In Vitro Synergism of Fluconazole and Berberine Chloride against Clinical Isolates of Candida albicans Resistant to Fluconazole

Department of Pharmacology, School of Pharmacy, Second Military Medical University,¹ Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University,² Department of Organic Chemistry, School of Pharmacy, Second Military Medical University,³ Department of Dermatology, Changhai Hospital of Second Military Medical University, Shanghai 200433, People's Republic of China⁴

Received 21 August 2005/ Returned for modification 1 October 2005/ Accepted 11 December 2005

In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.

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